Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center

Authors

Keywords:

Diabetes Mellitus, Glycated Hemaglobin, Lipid profile

Abstract

Introduction: Diabetes is one of the major burdens of non-communicable disease causing morbidity and mortality. Glycated hemoglobin (HbA1c) has been used as a tool to monitor glycemic control in patients with type 2 diabetes mellitus and elevated HbA1c value is considered an independent risk factor for dyslipidemia.

Methods: A total of 120 patients with type 2 diabetes mellitus were enrolled in this cross-sectional study. Means with standard deviation were used for age, height, weight and fasting blood sugar and Pearson correlation test was applied to identify correlation between Glycated hemoglobin (HbA1c) and lipid profile. Comparison of means was done by Student 't' test in parametric data within the two groups. P value less than 0.05 was considered significant.

Results: The mean HbA1c of male and female patients were 8.35±1.77 and 8.65±1.95 respectively. Among patients with good glycemic control, mean total cholesterol and mean high density lipoprotein were higher than poor glycemic control patients. Patients with poor glycemic control had higher mean triglyceride and low density lipoprotein than good glycemic control patients. Correlation coefficient for various components of lipid profile and HbA1c were: total cholesterol (r=0.189, p=0.038, n=120), triglyceride (r=0.418, p<0.01, n=120), low density lipoprotein (r=0.673,p<0.01,n=120) and high density lipoprotein ( r=-0.683,p<0.01, n=120).

Conclusion: There was a significant moderate correlation between HbA1c and lipid profile. Lipid profile values were significantly higher in poor glycemic control than good glycemic control patients. Hence, HbA1c can be considered as a surrogate marker for dyslipidemia in type 2 DM patients.

Downloads

Download data is not yet available.
Abstract
70
PDF
203

Author Biographies

Tilchan Pandey, Lumbini Medical College Teaching Hospital, Palpa, Nepal

Lecturer, Department of Internal Medicine

Jivan Khanal, Lumbini Medical College Teaching Hospital, Palpa, Nepal

Associate Professor, Department of Internal Medicine

Krishan Chandra Godar, Crimson Hospital, Manigram, Rupandehi, Nepal

Consultant Physician

Downloads

Published

2020-12-02

How to Cite

Pandey, T., Khanal, J., & Godar, K. C. (2020). Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center. Journal of Lumbini Medical College, 8(2), 238–243. Retrieved from https://nepjol.info/index.php/JLMC/article/view/40837

Issue

Vol. 8 No. 2 (2020)

Section

Original Research Articles

License

Copyright (c) 2020 Tilchan Pandey, Jivan Khanal, Krishan Chandra Godar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The Journal of Lumbini Medical College (JLMC) publishes open access articles under the terms of the Creative Commons Attribution(CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

JLMC requires an exclusive licence allowing to publish the article in print and online.

The corresponding author should read and agree to the following statement before submission of the manuscript for publication,

License agreement
In submitting an article to Journal of Lumbini Medical College (JLMC) I certify that:

  1. I am authorized by my co-authors to enter into these arrangements.
  2. I warrant, on behalf of myself and my co-authors, that:
    • the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;
    • I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to JLMC are not in breach of any other obligation;
    • the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;
    • I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.
  3. I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0. If the law requires that the article be published in the public domain, I/we will notify JLMC at the time of submission, and in such cases the article shall be released under the Creative Commons 1.0 Public Domain Dedication waiver. For the avoidance of doubt it is stated that sections 1 and 2 of this license agreement shall apply and prevail regardless of whether the article is published under Creative Commons Attribution License 4.0 or the Creative Commons 1.0 Public Domain Dedication waiver.
  4. I, and all co-authors, agree that, if the article is editorially accepted for publication in JLMC, data included in the article shall be made available under the Creative Commons 1.0 Public Domain Dedication waiver, unless otherwise stated. For the avoidance of doubt it is stated that sections 1, 2, and 3 of this license agreement shall apply and prevail.

Please visit Creative Commons web page for details of the terms.