Histomorphological Spectrum of Lesions in Nephrectomy Specimen

Authors

  • Dipika Basnet Dhulikhel hospital, Kathmandu university hospital, dhulikhel, Nepal
  • Ramesh Makaju Kathmandu University School of Medical Sciences
  • Rachana Dhakal Kathmandu University School of Medical Sciences https://orcid.org/0000-0003-2189-8369
  • Binita Lama Kathmandu University School of Medical Sciences
  • Nikita Gautam Kathmandu University School of Medical Sciences https://orcid.org/0000-0002-3970-9223

DOI:

https://doi.org/10.3126/jcmsn.v17i2.36322

Keywords:

chronic pyelonephritis; nephrectomy; clear cell renal cell carcinoma.

Abstract

Background

Nephrectomy is a common and standard surgical practice in urology. It  has pivotal role in diagnosis, treatment and prognosis of disease.  It is indicated in patients with irreversible kidney damage following chronic infection, trauma, obstruction and malformation as well as renal malignancy. The objective of this study was to analyze the histomorphological spectrum of various lesions in nephrectomy specimens with special emphasis on grading and staging of renal carcinoma.

Methods

This is a retrospective study done from January 2015 to December 2020 in the Department of  Pathology, Dhulikhel Hospital - Kathmandu University Hospital (DH - KUH). Relevant clinical data of the patients were obtained from the histopathological records of the patient from the pathology department.

Results

A total of 70 cases were studied, out of which 60 were simple nephrectomy specimens, followed by 8 radical and 2 partial nephrectomy specimens. The age of patient ranged from 2 to 74 years. Highest percentage of  nephrectomy was  seen in 4th decade of life.  Male population comprising 54.28% of nephrectomy. Non-neoplastic lesions constituted 53 cases and chronic pyelonephritis was the most common lesion. Out of 17 neoplastic lesions, 76.47% of cases were malignant. Clear cell renal cell carcinoma was the most common malignant tumour.

Conclusions

This study gives a fair insight into the incidence of neoplastic and non-neoplastic lesions of kidney requiring nephrectomy in this institution.

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Author Biographies

Ramesh Makaju, Kathmandu University School of Medical Sciences

Department of pathology

Associate professor

Rachana Dhakal, Kathmandu University School of Medical Sciences

Department of Pathology

Assitant Professor

Binita Lama, Kathmandu University School of Medical Sciences

Department of Pathology

Lecturer

Nikita Gautam, Kathmandu University School of Medical Sciences

Department of Pathology

Lecturer

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Published

2021-06-30

How to Cite

Basnet, D., Makaju, R., Dhakal, R., Lama, B., & Gautam, N. (2021). Histomorphological Spectrum of Lesions in Nephrectomy Specimen. Journal of College of Medical Sciences-Nepal, 17(2), 93–100. https://doi.org/10.3126/jcmsn.v17i2.36322

Issue

Section

Original Articles