Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance

Authors

  • Xing Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Rajina Sahi BP Koirala Memorial Cancer Hospital, Chitwan
  • Yu-Yang Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Ju Wang Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Chun-Hui Li Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province

DOI:

https://doi.org/10.3126/jcmsn.v10i4.12970

Keywords:

Esophageal carcinoma, HPV 16-E6, Immunohistochemistry

Abstract

Background and Objective: The role of (Human Papilloma Virus) HPV in cancer of certain anatomical location, such as cervix, has been widely recognized. The present study was conducted to explore the association between HPV 16-E6 protein and esophageal squamous cell carcinoma.

Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Results: The expression of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had significant correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.

JCMS Nepal 2014; 10(4):1-5

 

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Published

2015-07-31

How to Cite

Zhao, X., Sahi, R., Zhao, Y.-Y., Wang, J., & Li, C.-H. (2015). Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance. Journal of College of Medical Sciences-Nepal, 10(4), 1–5. https://doi.org/10.3126/jcmsn.v10i4.12970

Issue

Vol. 10 No. 4 (2014)

Section

Original Articles

License

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