Comparative evaluation of ondansetron, palonosetron, and dexamethasone for antiemetic prophylaxis in cesarean section under spinal anaesthesia
Keywords:
Ondansetron; Palonosetron; Dexamethasone; Cesarean sectionAbstract
Background: Spinal anesthesia is the most common regional anesthesia used to provide surgical anesthesia for cesarean section. Nausea and vomiting are common symptoms experienced by patients undergoing cesarean section.
Aims and Objectives: The aim of this study was to assess and compare the efficacy of dexamethasone, ondansetron, and palonosetron in prevention of nausea and vomiting.
Materials and Methods: This prospective randomized study was conducted on total 90 patients undergoing cesarean section, divided in three groups of 30 patients each. Group O received 4 mg ondansetron i.v., Group P received palonosetron 075 mg i.v and Group D received 8 mg dexamethasone i.v. The incidence of nausea and vomiting was compared between the groups and side effects were assessed.
Results: Antiemetic prophylaxis reduced the overall incidence of nausea and vomiting. However, Palonosetron had a lower incidence of nausea and vomiting as compared to dexamethasone and ondansetron.
Conclusion: Our study concluded that Palonosetron had the lowest incidence of nausea and vomiting.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
