Melatonin versus gabapentin as premedication for anxiolysis and attenuation of hemodynamic response to laryngoscopy and intubation in general anesthesia

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DOI:

https://doi.org/10.3126/ajms.v15i11.67043

Keywords:

Anxiolytics; Melatonin; Gabapentin; General anesthesia; Perioperative pain

Abstract

Background: Perioperative anxiety adversely affects mental and physical well-being and it is associated with increased pain, stressor responses with general anesthesia (GA), and nausea-vomiting leading to delayed recovery. Recent studies have proven melatonin and gabapentin provide sedation, anxiolysis, and reduced pressure responses.

Aims and Objectives: This study aimed to compare melatonin and gabapentin as premedication for anxiolysis and attenuation of hemodynamic response to GA. Post-operative pain and sedation were also compared.

Materials and Methods: A total of 99 subjects (n=33 in each group) between 18 and 60 year of age, ASA I/II scheduled for elective abdominal surgeries of < 3h under GA were included in the study. Patients in Group A were administered melatonin (10 mg×2 tab.), those in Group B were administered gabapentin (400 mg×2 tabs), and those in control Group C were treated with Vitamin C (500 mg×2) before 2 h of surgery. At 0 min, 30 min, and 60 min assessments of anxiety, sedation, cognition, psychomotor function, and orientation were done.

Results: There were significantly low anxiety scores in Groups M and G compared to Group C at 60 min and 90 min (P=0.0000). Sedation score was significantly less in Group C patients compared to Group M and G at 30 min (P=0.0008), 60 min, and 90 min (P=0.0000) intervals. Heart rate and mean arterial pressure were increased in Group C patients as compared to Groups M and G.

Conclusion: This study showed that melatonin had more anxiolytic and less sedative action, so also cognitive functions and orientation were well preserved in melatonin-treated subjects than in gabapentin. Hemodynamic responses were comparable in melatonin- and gabapentin-treated patients.

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Published

2024-11-01

How to Cite

Kalpana Rajendra Kulkarni, Pradhan Monnaiah K, Padma S, & Hema Viswanath K. (2024). Melatonin versus gabapentin as premedication for anxiolysis and attenuation of hemodynamic response to laryngoscopy and intubation in general anesthesia. Asian Journal of Medical Sciences, 15(11), 17–23. https://doi.org/10.3126/ajms.v15i11.67043

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Original Articles