Role of soluble fms-like tyrosine kinase-1/placental growth factor ratio along with uterine artery Doppler for the prediction of pre-eclampsia – A case–control study

Authors

  • Sathya Jagdish Assistant Professor, Department of Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India https://orcid.org/0000-0001-6249-7401
  • Kiruthiga T Assistant Professor, Department of Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India https://orcid.org/0000-0003-4179-9288
  • Shruthi Prashanth Assistant Professor, Department of Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India https://orcid.org/0000-0003-3587-3226
  • Jaya Vijayaraghavan Emeritus Professor, Department of Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
  • Sinduja Thirumanagalam Palanisamy Associate Consultant, Department of Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India https://orcid.org/0009-0005-5111-1135

DOI:

https://doi.org/10.3126/ajms.v15i5.62900

Keywords:

Soluble fms-like tyrosine kinase-1; Placental growth factor; Uterine artery Doppler; Pre-eclampsia

Abstract

Background: Hypertensive disorders of pregnancy are becoming the leading cause of maternal morbidity and mortality worldwide and are responsible for 9–25% of deaths 1. They are believed to occur due to an imbalance between pro-angiogenic factors, like placental growth factor (PlGF) and anti-angiogenic factors, like soluble fms-like tyrosine kinase-1 (sFLT-1).

Aims and Objectives: The aim of the study was to evaluate the role of the sFLT-1/PlGF ratio along with uterine artery Doppler for the prediction of pre-eclampsia (PE).

Materials and Methods: The current study was a prospective case–control study conducted at Sri Ramachandra Medical College and Hospital, Chennai, from 2018 to 2020. Blood samples for sFLT-1 and PlGF and uterine artery Doppler were done in 100 pregnant mothers who are at 16–20-week gestation attending antenatal outpatient department in the Department of Obstetrics and Gynecology.

Results: We found that the mean sFLT-1 in high-risk group was 826.17 ng/L (standard deviation [SD]±251.31) compared to 924.69 ng/L (SD±360.61) in low-risk groups. The mean PlGF in the high-risk group was 23.07 ng/L (SD±4.68) compared to 27.43 ng/L (SD±5.62) in low-risk group. The mean sFLT-1/PlGF ratio was increased in high-risk group of about 39.68 (SD±22.77) compared to 35 (SD±16.98) in low-risk group. Women with high resistance uterine artery Doppler have 8.5 odds of getting PE compared to those with normal uterine artery Doppler.

Conclusion: According to our study, the sFLT-1/PlGF ratio carries more sensitivity (90%) and negative predictive value (74.19%) if we keep the value as 32.25 along with uterine Doppler rather than their individual values for the prediction of PE.

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Published

2024-05-01

How to Cite

Sathya Jagdish, Kiruthiga T, Shruthi Prashanth, Jaya Vijayaraghavan, & Sinduja Thirumanagalam Palanisamy. (2024). Role of soluble fms-like tyrosine kinase-1/placental growth factor ratio along with uterine artery Doppler for the prediction of pre-eclampsia – A case–control study. Asian Journal of Medical Sciences, 15(5), 133–138. https://doi.org/10.3126/ajms.v15i5.62900

Issue

Vol. 15 No. 5 (2024)

Section

Original Articles

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