Prevalence of different gallbladder pathologies and usefulness of mucin histochemistry in early diagnosis of metaplasia and carcinoma of gallbladder

Authors

DOI:

https://doi.org/10.3126/ajms.v15i5.61974

Keywords:

Gallbladder metaplasia; Carcinoma; Mucin histochemistry

Abstract

Background: Non-neoplastic and neoplastic diseases of gallbladder are most prevalent in northern and north-eastern states of Uttar Pradesh, Bihar, Orissa, West Bengal, and Assam in India. Chronic cholecystitis, the most common pathology of gallbladder is often associated with metaplasia of epithelium, leading to increased susceptibility to malignant transformation. Along with histopathological examination, mucin histochemistry is useful in early detection of metaplasia and thereby predicting metaplasia-dysplasia-carcinoma sequence.

Aims and Objectives: The objective of this study was to estimate the prevalence of neoplastic and non-neoplastic diseases of gallbladder and to determine the usefulness of mucin histochemistry in early diagnosis of metaplasia and carcinoma of gallbladder.

Materials and Methods: A cross-sectional observational study was conducted in R. G. Kar Medical College, Kolkata, over a period of 18 months. Total 401 cholecystectomy specimens were studied. In every case, following sequence of examinations was performed-gross examinations, histopathological examination, and mucin histochemistry.

Results: All the available information was meticulously documented in tables and charts, software was used to calculate the statistical significance and efficacy of mucin histochemistry as a diagnostic tool.

Conclusion: We found that mucin histochemistry is statistically significant and has positive predictive value in early diagnosis of metaplasia and carcinoma of gallbladder.

Downloads

Download data is not yet available.
Abstract
53
PDF
54

Downloads

Published

2024-05-01

How to Cite

Joydip Sen, Suchismita Chakrabarti, Urvee Sarkar, Saugata Kumar Bhattacharya, & Ruplekha Mitra Mustaphi. (2024). Prevalence of different gallbladder pathologies and usefulness of mucin histochemistry in early diagnosis of metaplasia and carcinoma of gallbladder. Asian Journal of Medical Sciences, 15(5), 214–217. https://doi.org/10.3126/ajms.v15i5.61974

Issue

Vol. 15 No. 5 (2024)

Section

Original Articles

License

Copyright (c) 2024 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).