Association of inflammatory markers, serum ferritin and high sensitive C reactive protein, with HbA1c and dyslipidemia in male patients of type 2 diabetes mellitus

Authors

  • Ravi Kant Associate Professor, Department of Biochemistry, Narayan Medical College and Hospital, Sasaram, Bihar, India https://orcid.org/0009-0007-8256-2216
  • Shashi Kala Kumari Associate Professor, Department of Pharmacology, Narayan Medical College and Hospital, Sasaram, Bihar, India
  • Rakesh Sinha Associate Professor, Department of Biochemistry, Narayan Medical College and Hospital, Sasaram, Bihar, India
  • Ranjeet Kumar Associate Professor, Department of Biochemistry, Narayan Medical College and Hospital, Sasaram, Bihar, India
  • Arun Kumar Professor, Department of Biochemistry, Narayan Medical College and Hospital, Sasaram, Bihar, India https://orcid.org/0000-0002-8800-0296

DOI:

https://doi.org/10.3126/ajms.v15i4.61885

Keywords:

Diabetes mellitus; High sensitivity C-reactive protein; Ferritin; Dyslipidemia; Glycated hemoglobin

Abstract

Background: Diabetes mellitus (DM) is a common metabolic disorder affecting insulin secretion, insulin sensitivity, or both, resulting in hyperglycemia. As it progresses, almost all systems including cardiovascular, nervous, renal, etc. are involved eventually manifesting as several health-related complications. As all the systems of the human body work in harmony with each other, development of insulin resistance, dyslipidemia, and setting in of chronic inflammatory states evidenced by the rise in inflammatory markers are interrelated.

Aims and Objectives: The aim of this study was to establish the correlation of the inflammatory markers, serum ferritin and high sensitivity C-reactive protein (hs-CRP), with glycated hemoglobin (HbA1c) and dyslipidemia in patients of type 2 DM.

Materials and Methods: The present cross-sectional study was carried out in the Department of Biochemistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand. A total of 80 male patients of type 2 DM aged between 40 and 60 years with blood HbA1c level of more than 6.5% were included in the study.

Results: The inflammatory markers hs-CRP and ferritin were found to be positively correlated with HbA1c, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol but negatively correlated with high-density lipoprotein-cholesterol.

Conclusion: Estimation of serum ferritin and hs-CRP can detect the ongoing inflammatory and free radical-mediated damages in diabetic patients at an early period before the development of diabetic-related complications such as atherosclerosis and myocardial infarction.

Downloads

Download data is not yet available.
Abstract
169
PDF
232

Downloads

Published

2024-04-01

How to Cite

Ravi Kant, Shashi Kala Kumari, Rakesh Sinha, Ranjeet Kumar, & Kumar, A. (2024). Association of inflammatory markers, serum ferritin and high sensitive C reactive protein, with HbA1c and dyslipidemia in male patients of type 2 diabetes mellitus. Asian Journal of Medical Sciences, 15(4), 78–83. https://doi.org/10.3126/ajms.v15i4.61885

Issue

Vol. 15 No. 4 (2024)

Section

Original Articles

License

Copyright (c) 2024 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).