A comparative study of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine in ultrasound-guided transverse abdominis plane block for post-operative analgesia in infraumbilical surgeries
Keywords:Transverse abdominis plane; Analgesia; Dexmedetomidine; Infraumbilical surgeries
Background: Transversus abdominis plane (TAP) block delivers excellent analgesia with few side effects. Previous research suggests that the efficacy and duration of the block can be increased by adding adjuvants such as dexmedetomidine to the local anesthetics.
Aims and Objectives: To compare the post-operative analgesic effectiveness of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine 1 μg/kg in US-guided TAP block in infraumbilical surgery patients.
Materials and Methods: Ultrasound-guided TAP block was given to sixty patients. Patients consented for infraumbilical surgery, and patients were randomly assigned to two groups: Group L received 20 mL of 0.25% levobupivacaine alone and Group LD received 20 mL of 0.25% levobupivacaine with dexmedetomidine 1 μg/kg. The efficacy of analgesia was measured in terms of degree and duration of analgesia; the post-operative pain was evaluated using a visual analog scale (VAS). The Chi-square test and Student’s t-test were used for statistical analysis.
Results: Result shows that there is no statistically significant difference in gender, age group, weight, height, BMI, and type of surgery between groups, with a P=0.40, 0.83, 0.37, 0.59, and 0.93, respectively. In addition, there is no statistically significant difference in the duration of surgery between the groups (P=0.63). However, it was observed statistically significant differences in the onset of analgesia requirement, duration of effect of analgesia, and the total anesthesia consumption between the experimental groups with a P=0.001, 0.001, and 0.001, respectively. No significant difference in VAS was observed initially but was significant in later hours.
Conclusion: Adding dexmedetomidine to 0.25% levobupivacaine enhanced the efficacy of the block and duration of post-operative analgesia compared to 0.25% levobupivacaine alone.
How to Cite
Copyright (c) 2023 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).