Assessment of clinical profile of patients with non-radiographic axial spondyloarthropathy in a tertiary health-care center

Authors

  • Saurabh Limaye Resident, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India https://orcid.org/0000-0003-4852-2003
  • Shraddha More Assistant Professor, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India https://orcid.org/0000-0002-8525-1524
  • Milind Nadkar Professor and Head, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India
  • Alhad Mulkalwar Intern, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India https://orcid.org/0000-0001-6236-3841
  • Hunaid Haider Intern, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India https://orcid.org/0000-0003-2844-6648
  • Sujay Jaju Intern, Department of Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India https://orcid.org/0000-0003-3812-6939

DOI:

https://doi.org/10.3126/ajms.v13i12.47576

Keywords:

Ankylosing spondylitis; X-ray; Sacroiliac joint; Non-radiographic axial spondyloarthropathy

Abstract

Background: Axial spondyloarthritis (nr-axSpA) is an inflammatory and immune-mediated condition comprising clinically differentiated ankylosing spondylitis (AS) and nonradiographic nr- axSpA. Clinically, as the name suggests, non-radiographic nr- axSpA has an absence of definitive plain X-ray evidence of structural damage to the sacroiliac joint.

Aims and Objectives: The aim of the study was to assess and evaluate the clinical profile of patients with non-radiographic axial spondyloarthropathy. 

Materials and Methods: This study was conducted in the department of Medicine over 18 months in a tertiary health care institution, being a prospective and observational type done with 43 subjects.

Results: We observed a major improvement as per ASDAS criteria present among 53.49% of subjects, followed by clinically significant improvement among 27.91% of subjects. About 18.60% of subjects did not show any improvement. About 9.3% of subjects showed radiological progression. Out of eight cases that did not show improvement, all presented with low back pain and morning stiffness. About 62.5% had peripheral arthritis. About 87.5% had Schober’s test positive, FABER test (62.50%) and sacroiliac joint tenderness found among 7.5% of subjects. A total of 4 (9.3%) patients showed radiological progression. All of them have low back ache and morning stiffness, and three of them having peripheral arthritis at presentation. We found that patients who showed progression had higher mean ESR and CRP (45 and 36.5, respectively) values and a very high disease activity as per ASDAS and BASDAI criteria.

Conclusion: There is a great scope and need for research to differentiate the magnetic resonance imaging (MRI) changes in the normal population against the ones patients with spinal diseases to be able to use MRI with precision in patients with non-radiographic axial spondyloarthropathy (nr-axSpA). As assessed, currently physiotherapy and NSAIDS are first line therapy for patients suffering from non-radiographic axial spondyloarthropathy.

Downloads

Download data is not yet available.
Abstract
70
PDF
94

Downloads

Published

2022-12-01

How to Cite

Limaye, S. ., More, S. ., Nadkar, M., Mulkalwar, A., Haider, H., & Jaju, S. (2022). Assessment of clinical profile of patients with non-radiographic axial spondyloarthropathy in a tertiary health-care center. Asian Journal of Medical Sciences, 13(12), 256–261. https://doi.org/10.3126/ajms.v13i12.47576

Issue

Vol. 13 No. 12 (2022)

Section

Original Articles

License

Copyright (c) 2022 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).