Association of uric acid as a risk factor in ischemic stroke – A hospital-based observational study

Authors

  • Jegan Mohan Yogiswaran Assistant Professor, Department of General Medicine, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India https://orcid.org/0000-0002-0815-2362
  • Sasthanathan Ganesan Associate Professor, Department of General Medicine, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India https://orcid.org/0000-0002-7329-421X
  • Sathyan Elangovan Assistant Professor, Department of General Medicine, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India https://orcid.org/0000-0001-7434-0313

DOI:

https://doi.org/10.3126/ajms.v13i10.47267

Keywords:

Ischemic stroke; Body mass index; Smoking; Uric acid

Abstract

Background: The second most prevalent cause of mortality globally, next to coronary artery disease, is stroke. In humans, uric acid is the final catabolite in the metabolism of purine.

Aims and Objectives: The aims of this study were to determine the importance of blood uric acid levels in stroke patients in South Indian population.

Materials and Methods: In this observational study, we evaluated acute stroke patients who were admitted to Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research (MAPIMS) Hospital from December 2021 to May 2022. One hundred patients meeting the inclusion standards were enrolled and divided into two groups randomly following acquisition of ethical approval and informed consent.

Results: In our study consisting of both study and control groups, low-density lipoprotein cholesterol (P=0.034), non-high-density lipoprotein cholesterol (HDL-C) (P=0.0127), total cholesterol (P=0.0196), HDL-C (P=0.042), and triglyceride (P=0.0266) were found to be statistically significant. Mean serum uric acid (SUA) level between cases (6.94±1.97 mg/dL) and controls (5.49±1.27 mg/dL) were also statistically significant (P=0.0306 and P=0.049).

Conclusion: Our study showed that stroke patients had a significant occurrence of hyperuricemia. In keeping cardiovascular risk factors such as diabetes, hypertension, triglyceride level, total cholesterol level, coronary heart disease, and tobacco use under control, SUA was observed to be substantially linked with the initial phase of ischemic stroke.

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Published

2022-10-01

How to Cite

Jegan Mohan Yogiswaran, Sasthanathan Ganesan, & Sathyan Elangovan. (2022). Association of uric acid as a risk factor in ischemic stroke – A hospital-based observational study. Asian Journal of Medical Sciences, 13(10), 112–116. https://doi.org/10.3126/ajms.v13i10.47267

Issue

Vol. 13 No. 10 (2022)

Section

Original Articles

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Copyright (c) 2022 Asian Journal of Medical Sciences

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