The role of cardiac T2* magnetic resonance imaging in the assessment of myocardial iron concentration in patients with beta-thalassemia major

Authors

  • Tushar M Kalekar Professor, Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India
  • Viraj P Shah Junior Resident, Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India https://orcid.org/0000-0002-3913-2807
  • Sameeh Uz Zaman Junior Resident, Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India
  • Saad Muhammad Jaweed Shaikh Junior Resident, Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India https://orcid.org/0000-0002-4563-5523
  • Rachit Khandelwal Junior Resident, Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India https://orcid.org/0000-0001-6773-2431

DOI:

https://doi.org/10.3126/ajms.v13i6.43049

Keywords:

Beta-thalassemia, Ferritin, Iron overload, Myocardial iron concentration, T2* cardiac magnetic resonance imaging

Abstract

Background: Beta-thalassemia is a group of inherited blood disorders that are characterized by reduced levels of functional hemoglobin. These patients require lifelong blood transfusions, leading to iron deposition in various tissues. Prompt detection of myocardial iron helps to assess the extent of myocardial damage and its complications.

Aims and Objectives: Our study aims to establish the role of T2* cardiac magnetic resonance imaging (MRI) and its comparison with serum ferritin levels in detecting iron overload in beta-thalassemia major (TM) patients.

Materials and Methods: This prospective study included 30 pediatric patients admitted to our institute with beta-TM. The patients underwent T2* cardiac MRI examinations, myocardial iron quantification was assessed, and patients were divided into groups based on the severity of iron overload.

Results: In this study, there were 18 males and 12 females. Out of the total studied cases, 15 (50%) showed no evidence of iron overload, 8 (26.67%) showed mild, 4 (13.33%) showed moderate, and 3 (10%) showed severe cardiac siderosis, based on the cardiac T2* values obtained.

Conclusion: T2* cardiac MRI is an accurate and invaluable tool that helps to detect iron overload in beta-TM.

Downloads

Download data is not yet available.
Abstract
218
PDF
164

Downloads

Published

2022-06-01

How to Cite

Tushar M Kalekar, Viraj P Shah, Sameeh Uz Zaman, Saad Muhammad Jaweed Shaikh, & Rachit Khandelwal. (2022). The role of cardiac T2* magnetic resonance imaging in the assessment of myocardial iron concentration in patients with beta-thalassemia major. Asian Journal of Medical Sciences, 13(6), 79–84. https://doi.org/10.3126/ajms.v13i6.43049

Issue

Vol. 13 No. 6 (2022)

Section

Original Articles

License

Copyright (c) 2022 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).