Antibiotic susceptibility and prevalence of Methicillin-resistant Staphylococcus aureus in different clinical isolates in a tertiary care hospital
DOI:
https://doi.org/10.3126/ajms.v13i6.43027Keywords:
MIC, MRSA, MSSA, Staphylococcus aureusAbstract
Background: Staphylococcus aureus is a Gram-positive cocci bacterium responsible for variety of infections. Emergence of Methicillin-resistant S. aureus (MRSA) strains has led to a greater threat in different clinical settings. Early identification of MRSA in different infections is an effective measure to prevent and treat such systemic infections.
Aims and Objectives: This study aims to isolate and identify MRSA with their antibiotic sensitivity in different clinical samples.
Materials and Methods: A total of 2041 clinical samples from January to June 2021were collected and processed at the Microbiology Department of Burdwan Medical College and Hospital. S. aureus was identified and their antibiotic susceptibility testing was determined. MRSA/methicillin-sensitive S. aureus (MSSA) were identified by cefoxitin disc (30 mcg/disc) and their susceptibility to vancomycin and MIC determined by Etest following British Society for Antimicrobial Chemotherapy (BSAC) guidelines.
Results: Of 2041 samples, 358 (13.36%) isolates were S. aureus, of which 207 (57.82 %) MRSA and 151 (42.18%) MSSA. Among the 207 MRSA isolates, 40% were from patients with sepsis, 18.36% from pyrexia of unknown origin, 12.56% from surgical site infection, and 10.62% from ventilator-associated events. The highest number (55.55%) of MRSA was isolated from blood followed by 27.05% of isolates were from pus. All the isolates were sensitive to vancomycin with MICs of 0.5 μg, 0.75 μg, 1.0 μg, and 1.5 μg according BSAC and also very good sensitivity to levofloxacin and piperacillin/tazobactam.
Conclusion: The increasing prevalence of MRSA is posing a real threat to the health-care system. Careful detection and judicious use of antibiotics are the only answer.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).