Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study

Authors

  • Sumati Kandi Assistant Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India https://orcid.org/0000-0002-4963-0359
  • Laxmi Kanta Panigraghy Assistant Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India
  • Harish chandra Dhamudia Assistant Professor, Department of General Surgery, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India https://orcid.org/0000-0001-5239-8573
  • Pradipta Kumar Patel Associate Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India
  • Panchanana Sethi Junior Resident, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India

DOI:

https://doi.org/10.3126/ajms.v13i8.42565

Keywords:

Dexmedetomidine; Intraperitoneal instillation; Postoperative pain; Ropivacaine

Abstract

Background: Dexmedetomidine now has become one of the frequently used drugs as part of a multimodal analgesic regimen to provide improved pain control at all perioperative stages for laparoscopic surgeries.

Aims and Objectives: In this prospective, double-blind, randomized, and control trial, we compared the postoperative analgesic efficacy of intravenous (IV) dexmedetomidine and intraperitoneal (IP) dexmedetomidine in laparoscopic cholecystectomy.

Materials and Methods: Sixty patients of the American Society of Anesthesiologists Grade I and II undergoing laparoscopic cholecystectomy were allocated into two groups. The patients in Group-IV had received 30 ml of 0.5 μg/kg Dexmedetomidine infusion intravenously plus 40 ml of Ropivacaine (30 mL of 0.5% Ropivacaine and 10 ml NS) intraperitoneally and in Group-IP received 30 ml NS intravenously and 40 ml of Ropivacaine plus Dexmedetomidine (30 mL of 0.5% Ropivacaine and 0.5 μg/kg Dexmedetomidine diluted in 10 ml NS) intraperitoneally after removal of the gallbladder. Patients were assessed during the first 24 h postoperatively for time to the first requirement of analgesia, total analgesic consumption, sedation, hemodynamics, side effects, and patient satisfaction.

Results: Time to first request of analgesia (min) was longer (216.46±42.19 vs. 108.03±48.77) and total analgesic consumption (mg) was lower (92.50±32.26 vs 115.0±38.056) in Group-IV than in Group-IP. A significant difference was observed in visual analogue score in Group-IV at 1 h, 2 h, 4 h postoperatively and in the patient satisfaction score (P=0.024) in comparison to Group-IP.

Conclusion: The postoperative analgesic effects and patient satisfaction, of low dose IV Dexmedetomidine plus IP instillation of Ropivacaine, are superior to low dose IP Dexmedetomidine added to Ropivacaine.

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Published

2022-08-01

How to Cite

Kandi, S., Panigraghy, . L. K. ., Dhamudia, H. chandra, Patel, P. K., & Sethi, P. (2022). Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study. Asian Journal of Medical Sciences, 13(8), 19–26. https://doi.org/10.3126/ajms.v13i8.42565

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Original Articles