Study on clinical profile and antibiotic sensitivity pattern of enteric fever patients in a tertiary care hospital of East India

Authors

  • Pradeep Chakraborty Professor and Head, Department of General Medicine, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India https://orcid.org/0000-0003-4971-0305
  • Sujata Mazumdar Associate Professor, Department of General Medicine, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India https://orcid.org/0000-0002-0175-3480
  • Shyamosree Mondal Senior Resident, Department of General Medicine, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India https://orcid.org/0000-0003-2935-7911
  • Sayan Choudhury Postgraduate Resident, Department of General Medicine, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India https://orcid.org/0000-0002-8622-806X

DOI:

https://doi.org/10.3126/ajms.v13i6.41803

Keywords:

Antibiotic sensitivity, Clinical profile, Enteric fever

Abstract

Background: Enteric fever is a global health problem which is endemic in the Indian subcontinent. With the changing pattern of clinical presentation and antibiotic sensitivity, physicians are facing a challenge to treat the disease in day-to-day practice.

Aims and Objectives: The purpose of this study is to know the clinical profile of enteric fever and to study the pattern of antimicrobial susceptibility among Salmonella species.

Material and Methods: This is an observational cross-sectional study including 50 cases of enteric fever admitted under General Medicine Department of a tertiary medical institute of Kolkata from January 2019 to December 2019, diagnosed on the basis of positive results found on blood culture, Widal test, and Typhi dot immunoglobulin M. Proper history taking, detailed clinical examinations, and relevant blood investigations were done.

Results: The mean age of patients was 21.16±5.72 years with 32 males and 18 females. Fever was the most common symptom, followed by anorexia, abdominal pain, and headache. The predominant sign was coated tongue seen in 20 (40%) patients with hepatomegaly in 4 (8%) and splenomegaly in 9 (18%) patients. Salmonella Typhi and Salmonella Paratyphi A were isolated in 32 (64%) cases and 5 (10%) cases, respectively, with 100% sensitivity to 3rd generation cephalosporins, azithromycin, and meropenem. Fluoroquinolone resistance was approximately 90%.

Conclusion: Widely varying clinical presentation makes early diagnosis and proper selection of antibiotics essential for the treatment and prevention of complications of enteric fever. Quinolone resistance still remains an area of concern.

Downloads

Download data is not yet available.
Abstract
135
PDF
166

Downloads

Published

2022-06-01

How to Cite

Pradeep Chakraborty, Sujata Mazumdar, Mondal, S., & Sayan Choudhury. (2022). Study on clinical profile and antibiotic sensitivity pattern of enteric fever patients in a tertiary care hospital of East India. Asian Journal of Medical Sciences, 13(6), 108–112. https://doi.org/10.3126/ajms.v13i6.41803

Issue

Vol. 13 No. 6 (2022)

Section

Original Articles

License

Copyright (c) 2022 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).