Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19

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DOI:

https://doi.org/10.3126/ajms.v12i12.39717

Keywords:

Type 2 diabetes mellitus, HbA1C, Serum ferritin, Severe acute respiratory syndrome coronavirus-2

Abstract

Background: Diabetics exhibit elevated serum ferritin level when compared to non-diabetic counterpart, indicates impact of its association with coronavirus disease 2019 (COVID-19) infection and disease progression. Ferritin is a key mediator of immune dysregulation through direct immunosuppression contributing to cytokine storm resulting in fatal outcome in COVID-19.

Aims and Objectives: This study aims to estimate serum ferritin in diabetic (cases) and non-diabetic (controls) COVID-19 patients and its correlation with their diabetic profile (FBS, PPBS, RBS, and HbA1C).

Materials and Methods: A retrospective case–control study conducted at Rajarajeswari Medical College and Hospital, Bengaluru, for a period of 8 months among diabetic and non-diabetic COVID-19 patients.

Results: The study population consisted of 957 individuals, out of them, 425 patients were type 2 diabetes mellitus and 532 were non-diabetic COVID-19-positive patients (controls). Diabetic profile parameters (FBS, PPBS, RBS, and HbA1c) and serum ferritin were significantly (P<0.05) high in cases as compared to controls. Among diabetic COVID-19, the glycated hemoglobin and serum ferritin showed a significantly positive correlation (r=0.55) with serum ferritin (mean=648.98±320.48).

Conclusion: Hyperferritinemia is more prevalent in diabetic COVID-19 individuals. Serum ferritin can be considered as a valuable biomarker to screen the diabetic and non-diabetic for the presence of hyperinflammation and to predict severity of COVID-19 infection so that it will help the clinician for proper management.

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Published

2021-12-01

How to Cite

Kumar, M., Bindu, C., Shyam, A., & Reena, R. (2021). Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19. Asian Journal of Medical Sciences, 12(12), 23–31. https://doi.org/10.3126/ajms.v12i12.39717

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Section

Original Articles