Clinical effects of two different doses of duloxetine compared to conventional analgesic therapy in patients with osteoarthritis knee

Authors

  • Arpita Choudhury Assistant Professor, Department of Anaesthesiology, Critical Care Medicine and Pain management, R G Kar Medical College and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0002-5929-9233
  • Dipasri Bhattacharya Professor and Head, Department of Anaesthesiology, Critical Care Medicine and Pain management, R G Kar Medical College and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0002-9001-1525
  • Rajasree Biswas Associate Professor, Department of Anaesthesiology, Critical Care Medicine and Pain management, R G Kar Medical College and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0001-5223-7913
  • Swati Saroha Junior Consultant, Department of Anaesthesiology, AMRI, Saltlake, West Bengal, India https://orcid.org/0000-0001-8218-9975
  • Nitisha Chakraborty Senior Resident, Department of Anaesthesiology, Critical Care Medicine and Pain management, R G Kar Medical College and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0001-9398-4464
  • Samrat Roy Senior Resident, Department of Anaesthesiology, Critical Care Medicine and Pain management, R G Kar Medical College and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0001-7802-4799

DOI:

https://doi.org/10.3126/ajms.v12i10.37479

Keywords:

Osteoarthritis of knee, Pain, Duloxetine, Lower doses, Efficacy, Adverse effects

Abstract

Background: Pain is the leading symptom of knee osteoarthritis (OA) leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor, has been demonstrated to have a centrally acting analgesic effect.

Aims and Objectives: To evaluate the efficacy and safety of two different doses of duloxetine and compare with conventional pharmacotherapy in treatment of chronic pain due to osteoarthritis of knee.

Materials and Methods: 90 patients with symptomatic knee OA were randomly divided into 3 groups to receive duloxetine 40 mg & 3g paracetamol/day (Group A), duloxetine 20 mg & 3g paracetamol/day (Group B) and paracetamol 3gm/day (Group C). Patients were followed up for 6 months to assess pain relief and functional improvement. Visual Analogue Scale (VAS) for assessing pain intensity and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire physical function subscale for assessing physical function were used.

Results: Reduction in VAS score from baseline was significantly high in groups A and B as compared to C at 1 month, 3 months and 6 months. Reduction in WOMAC score from baseline were also significantly high in groups A and B as compared to C at 1 month, 3 month and 6 months. Adverse effects in Group A were significantly high as compared to group B and C. Patients discontinuing due to adverse effects were significantly high in group A.

Conclusion: Lower dose of duloxetine is associated with significant pain reduction and improved function with lesser adverse effects in patients with pain due to knee OA.

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Published

2021-10-01

How to Cite

Choudhury, A., Bhattacharya, D., Biswas, R., Saroha, S., Chakraborty, N., & Roy, S. . (2021). Clinical effects of two different doses of duloxetine compared to conventional analgesic therapy in patients with osteoarthritis knee. Asian Journal of Medical Sciences, 12(10), 97–104. https://doi.org/10.3126/ajms.v12i10.37479

Issue

Vol. 12 No. 10 (2021)

Section

Original Articles

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