Chance that matter or matter of chance: changing prevalence of fundic gland polyps and proton pump inhibitors

Authors

DOI:

https://doi.org/10.3126/ajms.v12i5.34418

Keywords:

Fundic Gland Polyps, Gastric Polyps, Helicobacter pylori, Prevalence, Proton Pump Inhibitors

Abstract

Background: Proton pump inhibitors (PPI) are considered one of reasons for changing prevalence of gastric fundic gland polyps (FGP), not only in western world but trend is being seen in Asian countries as well.

Aims and Objective: This study was designed to evaluate prevalence of FGP and to look into endoscopic and histological profile of these polyps in PPI users and non-PPI users. We also assessed background gastric mucosal histology in FGP patients.

Materials and Methods: This is a retrospective observational study of 1800 cases. Medical records of patients who underwent esophagogastroduodenoscopy (EGD) in three gastroenterology centres between 2011 and 2019 were analysed at Noora super speciality Hospital, Kashmir; Northern India. Biopsy specimens of patients with FGP were reviewed by expert pathologists. PPI use was quantified as significant when Pantoprazole 40 mg per day or equivalent doses of other PPI was used four times or more per week for more than one year. Statistical Analysis was conducted using SPSS version 22.

Results: FGP were most common, observed in 900 (50%) of all gastric polyp cases. PPI use one year and more was noted only in 360 (40%). FGP were mostly located in fundus 630 (70%), multiple in 840 (93.33%), with average size between 6 to 10 mm. On histology parietal cell hyperplasia, parietal cell protrusion and foveolar hyperplasia were seen in 666 (74%), 716(79.55%) and 254 (28.22%) cases respectively. Background gastric histology was normal in 543 (60.33%).

Conclusions: FGP were most common gastric polyps in Northern India. We observed similar endoscopic and histological characters in FGP irrespective of whether cases were using PPI or not. Majority of cases had normal background gastric mucosal histology.

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Author Biographies

Muzzafer Mohamad Mir, Noora Hospital; Srinagar; Jammu Kashmir: India

Consultant Gastroenterologist

Afaq Ahmad Khan, Assistant Professor, Department of Haematology, Sheri Kashmir Institute of Medical Science, Srinagar; Jammu Kashmir, India

Assistant Professor

Iqbal Baba, Assistant Professor, Department of Pathology, Government Medical College Baramulla, Jammu Kashmir, India

Assistant Professor

Showket Mir, Consultant Pathologist, Department of Health and Medical Education, Jammu Kashmir, India

Consultant Pathologist

Majid Rather, DNB Scholar, Department of Gastroenterology, Srinagar, Jammu Kashmir, India

DNB Scholar

Shaheen Lone, Registrar, Department of Gastroenterology, Srinagar, Jammu Kashmir, India

Registrar

Akhter Raina, Consultant Medicine, Department of Health and Medical Education, Jammu Kashmir, India

Consultant Medicine

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Published

2021-05-01

How to Cite

Wani, Z. A., Mir, M. M., Khan, A. A., Baba, I., Mir, S., Rather, M., Lone, S., & Raina, A. (2021). Chance that matter or matter of chance: changing prevalence of fundic gland polyps and proton pump inhibitors. Asian Journal of Medical Sciences, 12(5), 107–112. https://doi.org/10.3126/ajms.v12i5.34418

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Section

Original Articles