A Study on Urinary Glycated Albumin to urinary albumin excretion in gestational diabetes mellitus

Authors

DOI:

https://doi.org/10.3126/ajms.v12i2.32471

Keywords:

Gestational diabetes mellitus, Glycated albumin, Advanced glycation end products

Abstract

Background: Gestational Diabetes Mellitus (GDM) is a public health problem in India with implications well pronounced in pregnancy and beyond. Biomarkers like Glycated Albumin (G.A.) can well monitor the glycaemic status and evaluate the transient hyperglycaemic spikes, which account for the diabetic complications.

Aims and Objectives: In this study, we intend to study urinary G.A. excretion with respect to urinary albumin excretion expressed as UGA% in gestational diabetes mellitus.

Materials and Methods: A prospective observational study was conducted for a period of 16 months on 177 pregnant women who attended antenatal clinics for the first time at a single centre.Among the surveyed population, 26 pregnant women subsequently developed GDM, and 31 healthy pregnant women who did not develop GDM were included in the study.

Results: The UGA% between GDM and healthy mothers showed an increase in GDM with a p value <0.05 during the first and second trimesters. Pearson’s correlation coefficient at 5% interval showed moderate to strong correlation for fasting plasma glucose (FBS) vs UGA% in 1st trimester(r= 0.61) and 3rd trimester(r=0.54).

Conclusion: The higher UGA% in GDM mothers in the early trimester may help monitor glycaemic status efficiently and timely. Long term follows up would be worthwhile to predict future progression to nephropathy, retinopathy, and neuropathy. Henceforth, UGA being a non-invasive marker may emerge as a more patient-friendly marker reducing the hassles of innumerable invasive tests to monitor the well-being of a mother as
well as a foetus during pregnancy.

Downloads

Download data is not yet available.
Abstract
219
PDF
325
Cover AJMS 12(2)

Downloads

Published

2021-02-01

How to Cite

Paul, C., Banerjee, S., Mukhopadhyay, S., & Goswami, K. (2021). A Study on Urinary Glycated Albumin to urinary albumin excretion in gestational diabetes mellitus. Asian Journal of Medical Sciences, 12(2), 59–65. https://doi.org/10.3126/ajms.v12i2.32471

Issue

Vol. 12 No. 2 (2021)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).