Placental Lead and its Interaction with Some Essential Metals among Women from Lucknow, India

Authors

  • Jyoti Singh Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow
  • Vipul K Singh Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow
  • M Anand Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow
  • P Kumar Consultant Surgeon, Balrampur Hospital, Lucknow
  • MKJ Siddiqui Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow

DOI:

https://doi.org/10.3126/ajms.v1i2.3199

Keywords:

Placenta, Lead, Essential metals, parity, Atomic Absorption Spectrometer

Abstract

Objective: The placenta connects and separates two genetically distinct individuals: the mother and the fetus. There is no placental-fetal barrier blocking lead transport, placing the fetus at high risk from lead exposure. The placenta has been investigated as a possible indicator of environmental exposures. Recent studies have been focused on the interaction between toxic and essential metals in placenta as there is little information on the levels of lead and essential metals in human placental tissue in Indian scenario.
Material & Methods: The present study was designed to determine the status of lead and some essential metals in placental tissue of women residing in and around, Lucknow, India. Sixty pregnant women attending the local maternity home in the city were recruited to determine the concentrations of lead (toxic metal) and zinc, copper, iron & calcium (essential metals) using atomic absorption spectrophotometry.
Results: The mean±SD levels of placental lead was 0.35 ± 0.30μg/g which is lower than those reported in Australia (0.56μg/g) & Poland (0.50μg/g), and slightly higher than Spain (0.11μg/g). The mean ± SD (range) of placental zinc, copper, iron & calcium was found to be 7.67± 2.99 μg/g (0.47-13.75), 1.03 ± 0.55 μg/g (0.49-3.41), 76.42 ± 20.13 μg/g (17.67-135.25), 90.46 ± 112.47 μg/g (1.77-420.5) respectively. On the basis of parity, placental lead level was significantly higher (p<0.05), while copper and zinc were significantly lower (p<0.05, p<0.01 respectively) in multipa-rous cases as compared to nulliparous. Placental lead levels had significant negative correlation with zinc levels (r= -0.35, p<0.05).
Conclusion: The results suggested that increased lead level affect the essential metal level and its level increased with parity whereas, there was a depletion of maternal stores of essential elements (Zn, Cu, Fe and Ca) with increasing parity.

Key Words: Placenta; Lead; Essential metals; parity; Atomic Absorption Spectrometer

DOI: 10.3126/ajms.v1i2.3199

Asian Journal of Medical Sciences 1 (2010) 32-36

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Author Biographies

Jyoti Singh, Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow

Vipul K Singh, Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow

M Anand, Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow

P Kumar, Consultant Surgeon, Balrampur Hospital, Lucknow

MKJ Siddiqui, Analytical Toxicology, Indian Institute of Toxicology Research (IITR), Lucknow

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Published

2011-01-14

How to Cite

Singh, J., Singh, V. K., Anand, M., Kumar, P., & Siddiqui, M. (2011). Placental Lead and its Interaction with Some Essential Metals among Women from Lucknow, India. Asian Journal of Medical Sciences, 1(2), 32–36. https://doi.org/10.3126/ajms.v1i2.3199

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Original Articles