Gestational perturbation of homocysteine metabolism reduces Spina bifida prevalence in Osun State, Nigeria

Authors

  • Emmauel Olufemi Akanni Haematology and Blood Transfusion Science Division, Department of Medical Laboratory Science, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4400, Osogbo. Osun State, Nigeria
  • Adebayo Lawrence Adedeji Department of Biochemistry, College of Health Sciences, Leadoke Akintola University of Technology, P.M.B 4000, Ogbomosho; Oyo State, Nigeria
  • Oyindamola Nike Oyinlola Haematology and Blood Transfusion Science Division, Department of Medical Laboratory Science, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4400, Osogbo. Osun State, Nigeria
  • Raufu Taiwo Azeez Haematology and Blood Transfusion Science Division, Department of Medical Laboratory Science, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4400, Osogbo. Osun State, Nigeria
  • David Bolaji Akinbo Haematology and Blood Transfusion Science Division, Department of Medical Laboratory Science, College of Medicine & Health Sciences, Afe Babalola University, P.M.B, 5454, Ado – Ekiti, Ekiti State. Nigeria. https://orcid.org/0000-0002-1415-2959

DOI:

https://doi.org/10.3126/ajms.v11i4.27715

Keywords:

Homocysteine, Spina bifida, Singleton Pregnancy, Folic acid, Transmethylation

Abstract

Background: Elevated maternal homocysteine concentration has been described as a consequence of disruptions in methionine and/or folate metabolism which is associated with adverse outcomes and several obstetric complications inclusive of neural tube defects in offspring such as spina bifida, preeclampsia and spontaneous abortion.

Aims and Objectives: The current study investigated the influence of maternal homocysteine metabolism in singleton pregnant women on the prevalence of Spina bifida in Osun State.

Materials and Methods: Sixty (60) subjects attending Ladoke Akintola University of Technology Teaching Hospital and State Specialist Hospital in Osogbo, Osun State were randomly recruited for the study which spanned from January 2018 through April 2018 involving 30 apparently healthy singleton pregnant women classified according to gestational age and 30 apparently healthy age- and socio-economic status-matched non-pregnant women as controls. Haematocrit, haemoglobin concentration, total white cell count as well as the levels of homocysteine concentration were assessed.

Results: Haematocrit and haemoglobin concentration in all three trimesters were significantly (p< 0.05) decreased when compared with their non-pregnant counterparts. There was however a significant (p< 0.05) increase in the expression of circulating homocysteine in all three trimesters compared to the control group, and an observed steady decline in the second trimester through the third trimester.

Conclusion: These findings therefore imply that gestational perturbation of homocysteine metabolism may contribute to reduced risk of spina bifida in Osun State, Nigeria.

Downloads

Download data is not yet available.
Abstract
312
PDF
247
Cover 11(4)

Downloads

Published

2020-07-01

How to Cite

Akanni, E. O., Adedeji, A. L., Oyinlola, O. N., Azeez, R. T., & Akinbo, D. B. (2020). Gestational perturbation of homocysteine metabolism reduces Spina bifida prevalence in Osun State, Nigeria. Asian Journal of Medical Sciences, 11(4), 35–39. https://doi.org/10.3126/ajms.v11i4.27715

Issue

Vol. 11 No. 4 (2020)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).