Protective assessment of cimetidine against cyclophosphamide-induced kidney injury

Authors

DOI:

https://doi.org/10.3126/ajms.v9i6.20669

Keywords:

Cyclophosphamide, Kidney, Toxicity, Cimetidine, Prevention, Albino Rats

Abstract

Background: Nephrotoxicity is one of the frequent toxicities observed with cyclophosphamide (CP) use which may involve oxidative stress. Cimetidine is an antihistamine with anti-oxidative stress activity.

Aims and Objectives: The study aimed to evaluate the effect of cimetidine on cyclophosphamide-induced kidney damage in albino rats.

Materials and Methods: Forty eight adult rats randomised into 8 (A-H) groups of 6 rats per group were experimentally used for this study.Group A (control) was treated with water, while groups B-D were treated with 5, 10 and 20 mg/kg of cimetidine intraperitoneally (ip) daily for 5 days respectively. Group E was treated with150 mg/kgof CP ip on the 5th day. Groups F-H were pretreated with 5, 10 and 20 mg/kg cimetidine ip daily for 5 days and treated with CP ip on the 5th day respectively. Rats were sacrificed serum was extracted from blood and evaluated for renal function markers, while kidneys were harvested and evaluated for oxidative stress markers and histology.

Results: There were no significant effects (p>0.05) on the body and kidney weights of CP-treated rats. However, impaired kidney functions in CP-treated rats were marked by significant (p<0.05) increases in creatinine, urea, uric acid, sodium, potassium, chloride, bicarbonate, and malondialdehyde levels when compared to control. On the other hand, significant (p<0.05) decreases in superoxide dismutase, catalase, glutathione, glutathione peroxidase, total protein and albumin were obtained in CP-treated rats when compared to control. Necrotic changes were observed in the kidneys of CP-treated rats. However, CP-induced nephrotoxic effects were significantly (p<0.05; 0.01) reversed in cimetidine pretreated rats.

Conclusion: Cimetidine shows potential as adjunct remedy for cyclophosphamide associated nephrotoxicity.

Asian Journal of Medical Sciences Vol.9(6) 2018 25-30

Downloads

Download data is not yet available.
Abstract
624
PDF
632

Downloads

Additional Files

Published

2018-10-29

How to Cite

Adikwu, E., & Bokolo, B. (2018). Protective assessment of cimetidine against cyclophosphamide-induced kidney injury. Asian Journal of Medical Sciences, 9(6), 25–30. https://doi.org/10.3126/ajms.v9i6.20669

Issue

Vol. 9 No. 6 (2018)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).