An experimental study to see the antihypertensive effects of gymnema sylvestre and acorus calamus in wistar rats and its comparison with amlodipine

Authors

DOI:

https://doi.org/10.3126/ajms.v8i3.16778

Keywords:

Blood pressure, High fat diet, Extract, Obesity, Rats

Abstract

Background: The prevalence of obesity is increasing worldwide. Obesity has a direct correlation with insulin resistance and various cardiovascular diseases like hypertension,
dyslipidaemia etc. Hypertension is considered as a major independent risk factor for coronary disease and stroke for all age, race & sex groups. Gymnema sylvestre and Acorus calamus are two well known herbs of traditional system of medicine effective in various diseases.

Aims and Objectives: The present study was designed to explore the antihypertensive effects of Gymnema sylvestre (GS) and Acorus calamus (AC), individually as well as in combination, in wistar rats.

Materials and Methods: Female wistar rats, weighing between 150- 200 g, were included in the study. They were divided into eight groups with six rats in each group. High Fat diet (HFD) was used to induce hypertension in all the groups except group 1 which was fed with normal rodent diet. Drugs were given to the rats by oral feeding cannula.

Results: Feeding rats with HFD for 4 weeks lead to signifi cant increase in the mean systolic blood pressure. Both Gymnema sylvestre and Acorus calamus signifi cantly reduced the systolic blood pressure. Combination of both these (Gymnema sylvestre 200mg/kg and Acorus calamus 200mg/kg) as well as Gymnema sylvestre (200mg/kg) individually has an effect comparable to Amlodipine. Individual drugs had no signifi cant effect on heart rate while the combination of these two drugs signifi cantly reduced the heart rate.

Conclusions: The present study concludes that extracts of Gymnema sylvestre and Acorus calamus has a signifi cant antihypertensive action in rodent model of hypertension. Combination is found superior to the individual drugs.

Asian Journal of Medical Sciences Vol.8(3) 2017 11-15

Downloads

Download data is not yet available.
Abstract
1425
PDF
1106

Downloads

Additional Files

Published

2017-05-02

How to Cite

Singh, D. K., Kumar, N., Sachan, A., Lakhani, P., Tutu, S., Shankar, P., Nath, R., Sachan, A. K., & Dixit, R. K. (2017). An experimental study to see the antihypertensive effects of gymnema sylvestre and acorus calamus in wistar rats and its comparison with amlodipine. Asian Journal of Medical Sciences, 8(3), 11–15. https://doi.org/10.3126/ajms.v8i3.16778

Issue

Vol. 8 No. 3 (2017)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).