Association of perioperative hyperglycemic state with postoperative infection

Authors

  • J P Ghildiyal Professor, Department of Surgery, Hind Institute of Medical Sciences, Ataria,Sitapur,UP
  • Archna Ghildiyal Associate Professor, Department of Physiology, King George's Medical University Lucknow, UP, India
  • Sarsij Sharma Senior Resident, Department of Plastic Surgery, Safdarjang Hospital,New Delhi
  • Bushra Iqbal PhD Student, Department of Physiology, King George's Medical University, Lucknow,UP
  • Shraddha Singh Professor, Department of Physiology, King George's Medical University Lucknow, UP, India

DOI:

https://doi.org/10.3126/ajms.v7i6.15336

Keywords:

Perioperative, Hyperglycemia, Infections, Postoperative

Abstract

Background: Perioperative hyperglycemia is frequently encountered in clinical practice. Recent evidence suggests that hyperglycemia plays a significant role in the development of postoperative infections (POI). Major focus has been placed on whether hyperglycemia, as an independent risk factor, is associated with increased infection. The optimal targeted blood glucose range to prevent POI remains unclear, especially in the intra-operative period.

Aims and Objectives: To study the association between  peri-operative hyperglycemia to the subsequent risk of post-operative infections through a prospective  observational study.

Materials and Methods: A prospective study of 101 patients undergoing different types of general surgery procedures followed up to 30 days post-operatively was done. Random  blood Sugar (RBS) was taken (1) Pre-operatively (2) Intra-operatively (3) Postoperatively- after 6, 24 and 48 hours. Primary end points of the study were (1)  Surgical wound infection (2) Urinary tract infection (3) Septicemia.

Results: Out of 101 patients 57 developed perioperative hyperglycemia (incidence- 56.4%). In normoglycemic  group of patients infection rate was 4.5% (2/44) as compared to 26.3% (15/57) in perioperative hyperglycemic group.

Conclusion: The present study provides a convincing evidence of an association between perioperative hyperglycemia and post-operative infection apart from giving a possible relationship between preoperative blood sugar levels and postoperative infection.

Asian Journal of Medical Sciences Vol.7(6) 2016 32-35

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Author Biographies

J P Ghildiyal, Professor, Department of Surgery, Hind Institute of Medical Sciences, Ataria,Sitapur,UP

Professor and Head,Department of Surgery

Archna Ghildiyal, Associate Professor, Department of Physiology, King George's Medical University Lucknow, UP, India

ASSOCIATE PROFESSOR

DEPARTMENT OF PHYSIOLOGY

KGMU,LUCKNOW

UP,INDIA

Sarsij Sharma, Senior Resident, Department of Plastic Surgery, Safdarjang Hospital,New Delhi

Senior Resident,Department of Plastic Surgery

Bushra Iqbal, PhD Student, Department of Physiology, King George's Medical University, Lucknow,UP

PhD,Department of Physiology

Shraddha Singh, Professor, Department of Physiology, King George's Medical University Lucknow, UP, India

 PROFESSOR

DEPARTMENT OF PHYSIOLOGY

KGMU,LUCKNOW

UP,INDIA

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Additional Files

Published

2016-10-31

How to Cite

Ghildiyal, J. P., Ghildiyal, A., Sharma, S., Iqbal, B., & Singh, S. (2016). Association of perioperative hyperglycemic state with postoperative infection. Asian Journal of Medical Sciences, 7(6), 32–35. https://doi.org/10.3126/ajms.v7i6.15336

Issue

Vol. 7 No. 6 (2016)

Section

Original Articles

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