Increased H2S synthesizing activity in plasma correlated to fasting blood glucose levels: A study in type 2 diabetes patients

Authors

  • Pinaki Saha Junior Resident, Department of Biochemistry, Nilratan Sircar Medical College, Kolkata, West Bengal, India The West Bengal University of Health Sciences http://orcid.org/0000-0002-7591-1568
  • Sayantan Dasgupta Assistant Professor, Department of Biochemistry, Nilratan Sircar Medical College, Kolkata, West Bengal, India The West Bengal University of Health Sciences http://orcid.org/0000-0002-8483-7072
  • Sukla Nath Assistant Professor, Department of Biochemistry, Nilratan Sircar Medical College, Kolkata, West Bengal, India The West Bengal University of Health Sciences
  • Pradipta Ghosh Demonstrator, Department of Biochemistry, Malda Medical College West Bengal, India
  • Santanu Sen Associate Professor, Department of Biochemistry, Calcutta National Medical College West Bengal, India http://orcid.org/0000-0003-1964-9005
  • Tanmay Jyoti Sau Professor, Department of General Medicine, Calcutta Medical College West Bengal, India
  • Arun Kumar Professor, Department of Biochemistry, Gouri Devi Institute of Medical Sciences, Durgapur, West Bengal, India http://orcid.org/0000-0002-8800-0296
  • Utpal Kumar Biswas Professor, Department of Biochemistry, IPGMER, Ex-Prof and Head, Department of Biochemistry, Nilratan Sircar Medical College, Kolkata, West Bengal, India The West Bengal University of Health Sciences

DOI:

https://doi.org/10.3126/ajms.v7i6.15193

Keywords:

H2S synthesizing activity, FBG, Type 2 Diabetes

Abstract

Background: Diabetes mellitus is a major health problem not only in India but worldwide. Our country presently is undergoing an epidemic stage of this non-communicable disease.Though several etiological background of type 2 diabetes has been well explained, yet a number of recent literatures suggested a potential role H2S producing enzymes in the etiology and management of this metabolic disorder.

Aims and Objectives: Our aim was to elucidate the relationship of H2S synthesizing activity in plasma and fasting blood glucose in type 2 diabetic patients.

Materials and Methods: Sixty-two newly diagnosed type 2 diabetes patients and equal number of non-diabetic controls were included in the study. Enzymatic activity of synthesizing H2S in plasma was estimated following methods described earlier with further modification and standardization in our laboratory. All other parameters were estimated by using standardized kits.

Results:  FBG, PPBG, HbA1C, Fasting Insulin,  H2S synthesizing activity in plasma in patients are significantly higher (p< 0.05) than the corresponding values in healthy controls H2S synthesizing activity in plasma is positively correlated with fasting plasma glucose and the correlations is significant(p=0.05).

Conclusion: Our study though a pilot study with a small sample size, has elucidated that the values of H2S synthesizing activity in plasma are significantly elevated in type 2 diabetic patients and this may help researchers to develop H2S modifying agents and enzyme inhibitors which may open up new horizon in the treatment modalities of type 2 diabetes mellitus.

Asian Journal of Medical Sciences Vol.7(6) 2016 6-10

Downloads

Download data is not yet available.
Abstract
911
PDF
621

Author Biography

Pinaki Saha, Junior Resident, Department of Biochemistry, Nilratan Sircar Medical College, Kolkata, West Bengal, India The West Bengal University of Health Sciences

Resident of MD(Biochemistry) at Dept. of Biochemistry,N. R. S. Medical College, Kolkata, West Bengal, India,

Downloads

Published

2016-10-31

How to Cite

Saha, P., Dasgupta, S., Nath, S., Ghosh, P., Sen, S., Sau, T. J., Kumar, A., & Biswas, U. K. (2016). Increased H2S synthesizing activity in plasma correlated to fasting blood glucose levels: A study in type 2 diabetes patients. Asian Journal of Medical Sciences, 7(6), 6–10. https://doi.org/10.3126/ajms.v7i6.15193

Issue

Vol. 7 No. 6 (2016)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).