Expressions of HPV 16-E6 in esophageal carcinoma and it's clinical significance

Authors

  • Xing Zhao Hospital of Chengde Medical College, Chengde 067000, Hebei Province,
  • Rajina Sahi B.P. Koirala Memorial Cancer Hospital
  • Yu-Yang Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province,
  • Jun Wang Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province,
  • Chun- Hui Li Affiliated Hospital of Chengde Medical College,Chengde 067000, Hebei Province,

DOI:

https://doi.org/10.3126/ajms.v6i6.12537

Keywords:

Esophageal carcinoma, HPV 16-E6, Immunohistochemistry

Abstract

Aim: To explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.

Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Results: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma. 

DOI: http://dx.doi.org/10.3126/ajms.v6i6.12537

Asian Journal of Medical Sciences Vol.6(6) 2015 39-42

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Published

2015-06-10

How to Cite

Zhao, X., Sahi, R., Zhao, Y.-Y., Wang, J., & Li, C.-. H. (2015). Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance. Asian Journal of Medical Sciences, 6(6), 39–42. https://doi.org/10.3126/ajms.v6i6.12537

Issue

Vol. 6 No. 6 (2015)

Section

Original Articles

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