Screening of New Born Babies for Thyroid Stimulating Hormone, Glucose-6-Phosphate Dehydrogenase, 17-Hydroxyprogesterone and Sickle Cell Disease

Authors

  • Mukunda Raj Kalouni Department of Clinical Pathology, Manipal Teaching Hospital, Pokhara
  • Z G Badade Department of Biochemistry, MGM Medical College, Navi Mumbai
  • Nimain Mohanty Department of Paediatrics, MGM Medical College, Navi Mumbai
  • Bhup Dev Bhatta Department of Biochemistry, Manipal Teaching Hospital, Pokhara
  • Bhupendra R Pandey Department of Biochemistry, United Reference Laboratory, Pokhara
  • Rajendra Dev Bhatt Department of Biochemistry, KUSMS, Dhulikhel Hospital, Dhulikhel

DOI:

https://doi.org/10.3126/acclm.v1i2.13253

Keywords:

Thyroid stimulating hormone, 17-hydroxyprogesterone, Glucose-6 phosphate dehydrogenase, sickle cell, newborn screening

Abstract

BACKGROUND: The expanded newborn screening programme has now initiated worldwide. Many of the countries around the world made this programme mandatory. The effect of such screening system gives the advantage or betterment to the society as well as the nation.

METHODS: Samples were collected from babies aged 48-72 hours by heel prick method in a filter paper provided by Bio-Rad. The written consent was taken from the parents before collecting the blood samples. Blood samples were assayed for TSH and17-OHP by Enzyme Immuno Assay (EIA), G-6-PD was estimated by colorimetric assay provided by Bio-Rad Laboratories, USA and Sickle Cell Disease by sickling test

RESULTS: A total of 715 newborns were screened for TSH, G-6-PD, 17-OHP and Sickle cell disease. Out of which 1 neonate found abnormal (increased) thyroid stimulating hormone (1/715), and 8 neonates were G-6-PD deficient (8/715). We did not find any cases of congenital adrenal hyperplasia and sickle cell disease.

CONCLUSIONS: In this study the prevalence of Congenital Hypothyroidism and Glucose-6-Phosphate dehydrogenase deficiency was found to be 1:715 and 1:89 respectively. No cases of congenital adrenal hyperplasia and sickle cell disease were found.

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Author Biographies

Z G Badade, Department of Biochemistry, MGM Medical College, Navi Mumbai

Professor Biochemistry

Nimain Mohanty, Department of Paediatrics, MGM Medical College, Navi Mumbai

Professor, Pediatrics

Rajendra Dev Bhatt, Department of Biochemistry, KUSMS, Dhulikhel Hospital, Dhulikhel

Lecturer
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Published

2015-10-02

How to Cite

Kalouni, M. R., Badade, Z. G., Mohanty, N., Bhatta, B. D., Pandey, B. R., & Bhatt, R. D. (2015). Screening of New Born Babies for Thyroid Stimulating Hormone, Glucose-6-Phosphate Dehydrogenase, 17-Hydroxyprogesterone and Sickle Cell Disease. Annals of Clinical Chemistry and Laboratory Medicine, 1(2), 27–30. https://doi.org/10.3126/acclm.v1i2.13253

Issue

Vol. 1 No. 2 (2015)

Section

Original Articles

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