Effect of gonadotropins and alpha 2u-globulin on testicular steroidogenesis and spermatogenesis in melatonin-treated rats

Authors

  • R Biswas Department of Oncology, National Cancer Institute, Bethesda, Maryland,
  • NM Biswas Department of Medicine, NRS Medical College, Calcutta-14,
  • H Mandal Deceased before this communication
  • NM Biswas College of Medical Sciences, Bharatpur,

DOI:

https://doi.org/10.3126/jcmsn.v8i1.6819

Keywords:

Alpha 2u-globulin, gonadotropins, male gonad, melatonin

Abstract

Administration of melatonin (400?g/100g bd.wt.) for 14 days caused a fall in weights of the testes and accessory sex organs and testicular 17?-hydroxysteroid dehydrogenase (17?-HSD) but rise in 3?-hydroxysteroid dehydrogenase (3?-HSD) activity, decreased spermatogenesis, serum level of gonadotropins, testosterone and alpha 2u-globulin, The animals treated with melatonin when received gonadotropins or alpha 2u-globulin for the last seven days reversed the weight of testis and accessory sex organs, 3?-HSD, 17?-HSD activities, serum level of gonadotropins, testosterone and alpha 2u-globulin when compared with melatonin-treated rats. It is concluded that alpha 2u-globulin prevents testicular degeneration in melatonin-treated rats by stimulating the synthesis of gonadotropins.

Journal of College of Medical Sciences-Nepal,2012,Vol-8,No-1, 7-12

DOI: http://dx.doi.org/10.3126/jcmsn.v8i1.6819

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Published

2012-09-11

How to Cite

Biswas, R., Biswas, N., Mandal, H., & Biswas, N. (2012). Effect of gonadotropins and alpha 2u-globulin on testicular steroidogenesis and spermatogenesis in melatonin-treated rats. Journal of College of Medical Sciences-Nepal, 8(1), 7–12. https://doi.org/10.3126/jcmsn.v8i1.6819

Issue

Vol. 8 No. 1 (2012)

Section

Original Articles